The GenapSys Sequencer


Update your expectations about how accurate, scalable and affordable DNA sequencing can be. The GenapSys Sequencer is based on our novel and robust sequencing technology. The system utilizes the first ever purely electrical sequencing chip, the key component in our fully integrated proprietary platform. Our proprietary NGS technology with proven Sequencing-by-Synthesis (SBS) chemistry employs electrical-based detection of single nucleotide incorporations. With CMOS-based detectors (Complementary Metal Oxide Semiconductor), simple fluidics, and no moving parts, the GenapSys Sequencer is compact, robust, easy to use, and inexpensive. Sequencing is carried out on microfluidic chips that have a scalable number of detectors, allowing for applications ranging from targeted sequencing of exomes and cancer panels to genome-scale data collection. Chips with different outputs can be run on the same low-cost instrument by simply swapping the consumable chip (1M or 16M) eliminating the need for expensive hardware upgrades.

Exceptional Accuracy

>80% of bases >Q30 validated by numerous applications in experienced third party labs.

The platform is capable of generating high-quality sequence data and delivers the high resolution and analytical sensitivity needed for detection of rare variants and transcripts. It routinely generates sequence data that exceeds >80% of bases >Q30 with average read lengths of up to 150 bp. An example of GenapSys’ high-quality data from a genomic library, generated at an external lab, is shown below.

Amazing Affordability

Low capital costs, low operating costs.

Shifting from optics to electrical based detection creates a substantial reduction in capital cost. The simplicity of the detection modality that does not require any optics, robots, scanners, or expensive analysis servers, allows for a lowcost and affordable instrument. The instrument list price puts sequencing within the reach of virtually any lab. The GenapSys Sequencer provides an affordable solution for Next-Generation Sequencing in labs of all types. The low per-run cost means reasonable cost per sample without excessive sample batching. Researchers can now dictate the pace of their work by performing runs at their own convenience, without having to wait for additional samples to be batched before starting a run. Additionally, researchers can maintain control of the sequencing process from beginning to end, providing higher confidence in sample integrity and data analysis results.

Unrivaled Scalability

A range of outputs tuned to your sample throughput needs.

Our sequencing platform offers the built-in capability to easily scale up simply by utilizing a different sequencing chip, all of which are capable of running on the same affordable instrument.

At the heart of our system are CMOS chips (Complementary Metal Oxide Semiconductor), the first chips that deliver purely electrical-based sequencing. Shifting from optical to electrical sequencing provides a cost-effective, scalable solution without the need for excessive sample batching.

The G3 chip, which is our commercially available product contains 16 million sensors and capable of generating 1.2-2.0 Gb of high quality sequence data with average read lengths of >150 bp. With future release of higher density chips, you can scale up your throughput whenever you want, without changing the underlying instrument. Existing hardware of the sequencer is forward compatible with future higher density chips.

Externally generated data with >80% of bases >Q30

1.6Gb run output, 11.2M reads​

Streamlined 4-step workflow using the GenapSys Platform

1. Library Preparation

The sequencer is compatible with a broad range of library preparation methodologies. Performance has been demonstrated across multiple kits.

2. Amplification

Addition of pooled libraries and run consumables is followed by a simple run setup process. Once in operation, the GenapSys Sequencing Prep System automates the clonal amplification procedure in an unattended 4-hour run. The final amplified product is then ready for sequencing.

3. Sequencing

Amplified material is loaded into a sequencing chip. The user-friendly system interface walks the user through consumables loading and the run setup procedure. The system uses our proprietary high accuracy SBS chemistry to deliver high-quality data.

4. Data Analysis

The sequencing run output is a standard FASTQ file. This allows for existing secondary analysis tools to be utilized for analysis of GenapSys data. For highest quality results, we recommend customers to use GenHub, our proprietary cloud hosted solution, to run secondary analyses with empirically derived, optimized parameters for GenapSys data. This obviates the need for expensive additional localized servers. Additionally GenHub provides customers real time monitoring of the status of the sequencing run as well as accessing FASTQ and VCF files of all runs.

Ordering Information

Product Catalog No. Description
GenapSys Sequencer 1001500 Sequencer and accessories. Comes with a standard 1-year warranty that includes depot repair, all parts and labor.
GenapSys Sequencing Prep System 1002470 System for automated clonal amplification and enrichment for the GenapSys Sequencer.
G3 Sequencing Kit V3, Dual Index 1001975 Kitted reagents and consumables for a single dual-index sequencing run. Includes a single ready-to-use sequencing cartridge and one G3 sequencing chip.
G3 Sequencing Kit V3, No Index 1001977 Kitted reagents and consumables for a single non-index sequencing run. Includes a single ready-to-use sequencing cartridge and one G3 sequencing chip.
G3 Amplification Kit V3 1001438 Kitted reagents and consumables for a single run of automated amplification on the Sequencing Prep System.

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