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SARS-CoV-2 Sequencing

The Coronavirus pandemic has highlighted the need for rapid and comprehensive genome information to enable the research and therapeutic development communities. The solutions they need must be robust, cost effective and distributable. Next-Generation Sequencing (NGS) provides an effective and comprehensive method to interrogate the full genome of the virus and its mutations. Sequencing of the SARS-CoV-2 genome is now available as an integrated solution from Genapsys. A multiplexed amplicon panel amplifies the viral genome enabling RNA to sequence-ready libraries in less than 6 hours. The Genapsys Sequencing Platform offers a rapid, distributable and economical method for sequencing of COVID 19 samples for disease surveillance and research. The automated reporting function removes the need for complex bioinformatic architectures and tools.

  • Decentralized and low cost NGS solution for surveillance and testing for the COVID-19 pandemic
  • Accurate detection of SARS-CoV-2 variants, with uniform genome coverage
  • Detection of a wide range of viral titers (5-orders of magnitude) and good performance at low read depths
  • Multiplex a large number of samples to enable higher throughput and a lower price per sample

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Targeted Sequencing

Targeted Sequencing is a variation of Sequencing where only a small subset of the genome is sequenced, such as the exome, a particular chromosome, a set of genes or a region of interest. By focusing all of the sequencing on a small region of the genome,
it is possible to detect low levels of variation that might have otherwise been missed. It is an important tool for Oncology research and variant calling.
Targeted sequencing on the GenapSys Sequencer focuses on regions of interest and avoids uninformative portions, to maximize sequencing utility and samples per run.

  • Robust sequencing of a set of genes or regions of interest
  • Low price per run and low price per sample
  • Wide range of throughputs suitable for various applications, with different chips. e.g. 16 million sensor chip, more than 1.2-2.0 Gb of highly accurate DNA sequence per run average read-length of >150 bps
  • Compatible with amplicon-based or hybridization capture-based libraries, and PCR products

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Small Genome Sequencing

Small genome sequencing (≤10 Mb) involves sequencing the entire genome of a bacterium, virus, archaea, or other microorganism, and then comparing the sequence to a known reference. Sequencing small microbial genomes can be useful for food testing, public health, infectious disease surveillance, molecular epidemiology studies, and environmental metagenomics.The GenapSys Sequencing Platform, using the 16M chip, generates 1.2 – 2.0 Gb of highly accurate sequencing output per run, and is the ideal tool for addressing these applications.

  • Robust sequencing of entire small genomes
  • Low price per run and low price per sample
  • More than 1.2 Gb of highly accurate DNA sequence per run
  • Highly uniform genome coverage for viruses, bacteria, and other microbes

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RNA Sequencing

RNA sequencing helps analyze the continuously changing cellular transcriptome, providing valuable information about the internal state of cells and transcriptional networks for disease research and a wide array of study conditions. It is a highly sensitive and accurate means of quantifying gene expression and delivers an a complete view of the coding transcriptome not governed by existing knowledge or research tools. The Genapsys Sequencing Platform offers a solution that enables an array of RNA sequencing approaches such as targeted RNA sequencing and small RNA sequencing.

  • Excellent gene expression concordance relative to alternate sequencing technologies
  • Interrogate thousands of small RNAs in parallel with greater sensitivity and dynamic range vs orthogonal methods
  • More than 10M highly accurate reads per run
  • Low price per run and low price per sample

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